| Phase I |
CYP1A2 |
cytochrome P450, family 1, subfamily A, polypeptide 2 |
15q24 |
| CYP2A6 |
cytochrome P450, family 2, subfamily A, polypeptide 6 |
19q13.2 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 |
19q13.2 |
| CYP2C8 |
cytochrome P450, family 2, subfamily C, polypeptide 8 |
10q23.33 |
| CYP2C9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 |
10q24 |
| CYP2C19 |
cytochrome P450, family 2, subfamily C, polypeptide 19 |
10q24.1-q24.3 |
| CYP2D6 |
cytochrome P450, family 2, subfamily D, polypeptide 6 |
22q13.1 |
| CYP2J2 |
cytochrome P450, family 2, subfamily J, polypeptide 2 |
1p31.3-p31.2 |
| CYP2S1 |
cytochrome P450, family 2, subfamily S, polypeptide 1 |
19q13.1 |
| CYP3A4 |
cytochrome P450, family 3, subfamily A, polypeptide 4 |
7q21.1 |
| CYP3A5 |
cytochrome P450, family 3, subfamily A, polypeptide 5 |
7q21.1 |
| CYP3A7 |
cytochrome P450, family 3, subfamily A, polypeptide 7 |
7q21-q22.1 |
| CYP4F2 |
cytochrome P450, family 4, subfamily F, polypeptide 2 |
19pter-p13.11 |
| CYP4F11 |
cytochrome P450, family 4, subfamily F, polypeptide 11 |
19p13.1 |
| TBXAS1(CYP5A1) |
thromboxane A synthase 1 (platelet) |
7q34-q35 |
| CYP7A1 |
cytochrome P450, family 7, subfamily A, polypeptide 1 |
8q11-q12 |
| PGIS(CYP8A1) |
prostaglandin I2 (prostacyclin) synthase |
20q13.13 |
| CYP19A1 |
cytochrome P450, family 19, subfamily A, polypeptide 1 |
15q21.1 |
| ADH1B |
alcohol dehydrogenase 1B (class I), beta polypeptide |
4q21-q23 |
| ALDH2 |
aldehyde dehydrogenase 2 family (mitochondrial) |
12q24.2 |
| EPHX1 |
epoxide hydrolase 1, microsomal (xenobiotic) |
1q42.1 |
| Phase II |
UGT1A1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
2q37 |
| UGT1A3 |
UDP glucuronosyltransferase 1 family, polypeptide A3 |
2q37 |
| UGT1A4 |
UDP glucuronosyltransferase 1 family, polypeptide A4 |
2q37 |
| UGT1A5 |
UDP glucuronosyltransferase 1 family, polypeptide A5 |
2q37 |
| UGT1A6 |
UDP glucuronosyltransferase 1 family, polypeptide A6 |
2q37 |
| UGT1A7 |
UDP glucuronosyltransferase 1 family, polypeptide A7 |
2q37 |
| UGT1A8 |
UDP glucuronosyltransferase 1 family, polypeptide A8 |
2q37 |
| UGT1A9 |
UDP glucuronosyltransferase 1 family, polypeptide A9 |
2q37 |
| UGT1A10 |
UDP glucuronosyltransferase 1 family, polypeptide A10 |
2q37 |
| UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
4q13 |
| UGT2B15 |
UDP glucuronosyltransferase 2 family, polypeptide B15 |
4q13 |
| SULT1A1 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
16p12.1 |
| SULT1A2 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 |
16p12.1 |
| SULT1A3 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 |
16p11.2 |
| TPMT |
thiopurine S-methyltransferase |
6p22.3 |
| NAT2 |
N-acetyltransferase 2 (arylamine N-acetyltransferase) |
8p22 |
| Transcription factor |
NR0B2(SHP) |
nuclear receptor subfamily 0, group B, member 2 |
1p36.1 |
| NR1H3(LXRA) |
nuclear receptor subfamily 1, group H, member 3 |
11p11.2 |
| NR1H4(FXR) |
nuclear receptor subfamily 1, group H, member 4 |
12q23.1 |
| NR1I2(PXR) |
nuclear receptor subfamily 1, group I, member 2 |
3q12-q13.3 |
| NR1I3(CAR) |
nuclear receptor subfamily 1, group I, member 3 (constitutive androstane receptor) |
1q23.3 |
| TCF1(HNF1A) |
HNF1 homeobox A |
12q24.2 |
| NR2A1(HNF4A) |
nuclear receptor subfamily 2, group A, member 1 |
20q12-q13.1 |
| ONECUT1(HNF6) |
one cut homeobox 1 |
15q21.1-q21.2 |
| HIF1A |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
14q21-q24 |
| Transporter |
ABCB1(MDR1) |
?ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
7q21.1 |
| ABCC1(MRP1) |
ATP-binding cassette,sub family C (CFTR/MRP), member1 |
16p13.1 |
| ABCC2(MRP2) |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
10q24 |
| ABCC5(MRP5) |
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
3q27 |
| ABCG2(BCRP) |
ATP-binding cassette, sub-family G (WHITE), member 2 |
4q22 |
| SCN1A |
sodium channel, voltage-gated, type I, alpha subunit |
2q24.3 |
| SLC10A1(NTCP) |
solute carrier family 10 (sodium/bile acid cotransporter family), member 1 |
14q24.1 |
| SLC10A2(ASBT) |
solute carrier family 10 (sodium/bile acid cotransporter family), member 2 |
13q33 |
| SLC22A1(OCT1) |
solute carrier family 22 (organic cation transporter), member 1 |
6q26 |
| SLC22A2(OCT2) |
solute carrier family 22 (organic cation transporter), member 2 |
6q26 |
| SLC22A3(OCT3) |
solute carrier family 22 (extraneuronal monoamine transporter), member 3 |
6q26-q27 |
| SLC22A6(OAT1) |
solute carrier family 22 (organic anion transporter), member 6 |
11q13.1-q13.2 |
| SLC22A7(OAT2) |
solute carrier family 22 (organic anion transporter), member 7 |
6p21.2-p21.1 |
| SLC22A9(OAT7) |
solute carrier family 22 (organic anion transporter), member 9 |
11q13.1 |
| SLC22A12(URAT1) |
solute carrier family 22 (organic anion/urate transporter), member 12, SLC22A12 |
11q13.1 |
| SLC28A1(CNT1) |
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 |
15q25-26 |
| SLC28A2(CNT2) |
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 |
15q15 |
| SLC28A3(CNT3) |
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 |
9q22.2 |
| SLC29A1(ENT1) |
solute carrier family 29 (nucleoside transporters), member 1 |
6p21.1-p21.2 |
| SLC29A2(ENT2) |
solute carrier family 29 (nucleoside transporters), member 2 |
11q13 |
| SLCO1B1(OATPC) |
solute carrier organic anion transporter family, member 1B1 |
12p |
| SLCO1B3(OATP1B3) |
solute carrier organic anion transporter family, member 1B3 |
12p12 |
| SLCO2B1(OATP2B1) |
solute carrier organic anion transporter family, member 2B1 |
11q13 |
| SLC47A1(MATE1) |
solute carrier family 47 (multidrug and toxin extrusion), member 1 |
17p11.2 |
| Other |
ANXA6 |
annexin A6 |
5q32-q34 |
| APOE |
apolipoprotein E |
19q13.2 |
| CALU |
calumenin |
7q32.1 |
| CDA |
cytidine deaminase |
1p36.2-p35 |
| CDC27 |
cell division cycle 27 homolog (S. cerevisiae) |
17q12-q23.2 |
| CHD5 |
chromodomain helicase DNA binding protein 5 |
1p36.31 |
| DCK |
Deoxycytidine Kinase |
4q13.3-q21.1 |
| DKK3 |
dickkopf homolog 3 |
11p15.2 |
| EFNB2 |
ephrin-B2 |
13q33 |
| GABBR2 |
gamma-aminobutyric acid (GABA) B receptor, 2 |
9q22.1-q22. |
| GFRA1 |
GDNF family receptor alpha 1 |
10q26.11 |
| GGCX |
gamma-glutamyl carboxylase |
2p12 |
| GNA14 |
guanine nucleotide binding protein (G protein), alpha 14 |
9q21 |
| HLA-DRA |
major histocompatibility complex, class II, DR alpha |
6p21.3 |
| HLA-A |
HLA-A major histocompatibility complex, class I, A |
6p21.3 |
| HLA-B |
HLA-B major histocompatibility complex, class I, B |
6p21.3 |
| HLA-C |
HLA-C major histocompatibility complex, class I, C |
6p21.3 |
| HOMER2 |
homer homolog 2 |
15q24.3 |
| HPCAL1 |
hippocalcin-like 1 |
2p25.1 |
| IGF1R |
insulin-like growth factor 1 receptor |
15q26.3 |
| ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
13q33 |
| JARID2 |
jumonji, AT rich interactive domain 2 |
6p24-p23 |
| KIAA0317 |
KIAA0317 |
14q24.3 |
| KLKB1 |
kallikrein B, plasma (Fletcher factor) 1 |
4q34-q35 |
| KRT12 |
keratin 12 |
17q12 |
| LARS2 |
leucyl-tRNA synthetase 2, mitochondrial |
3p21.3 |
| LOC127406 |
ribosomal protein SA pseudogene 20 |
1p32.2 |
| MAD1L1 |
MAD1 mitotic arrest deficient-like 1 (yeast) |
7p22 |
| MTHFR |
5,10-methylenetetrahydrofolate reductase (NADPH) |
1p36.3 |
| MYO3B |
myosin IIIB |
2q31.1-q31.2 |
| NCOA1 |
nuclear receptor coactivator 1 |
2p23 |
| NQO1 |
NAD(P)H dehydrogenase, quinone 1 |
16q22.1 |
| OPRM1 |
opioid receptor, mu 1 |
6q24-q25 |
| P2Y12 |
purinergic receptor P2Y, G-protein coupled, 12 |
3q24-q25 |
| PON1 |
PON1,paraoxonase 1 |
7q21.3 |
| POR |
P450 (cytochrome) oxidoreductase |
7q11.2 |
| PROC |
protein C (inactivator of coagulation factors Va and VIIIa) |
2q13-q14 |
| PROS1 |
protein S (alpha) |
3q11.2 |
| RPS6KA2 |
ribosomal protein S6 kinase, 90kDa, polypeptide 2 |
6q27 |
| SEMA5A |
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
5p15.2 |
| SERPINC1 |
serpin peptidase inhibitor, clade C (antithrombin), member 1 |
1q23-q25.1 |
| ST6GALNAC3 |
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltran |
1p31.1 |
| TMEM99 |
transmembrane protein 99 |
17q21.2 |
| TRPS1 |
trichorhinophalangeal syndrome I |
8q24.12 |
| TTN |
titin |
2q31 |
| TYMS |
thymidylate synthetase |
18p11.32 |
| TYMP |
thymidine phosphorylase |
22q13.33 |
| VKORC1 |
vitamin K epoxide reductase complex, subunit 1 |
16p11.2 |
| WDR31 |
WD repeat domain 31 |
9q32 |
| IL28B |
interleukin 28B (interferon, lambda 3),IL28B |
19q13.13 |
| ITPA |
ITPA, inosine triphosphatase (nucleoside triphosphate pyrophosphatase) |
20p |
| C20orf194 |
chromosome 20 open reading frame 194, C20orf194 |
20p13 |
| ZIM2 |
zinc finger, imprinted 2 |
19q13.4 |
