- 임상약물유전체학
  - 약물분석/대사체학
 
1) 임상약물유전체학 (Clinical Pharmacogenomics)
주요연구분야

 1) Tailored pharmacotherapy

 2) Pharmacokinetic and pharmacodynamic study in relation to pharmacogenetics

 3) Pharmacogenetic epidemiology

 4) Pharmacogenetics in the drug discovery and development

 
2) 약물분석/대사체학
주요연구분야

 1) Drug Metabolism/Pharmacokinetics

 2) PharmacoMetabolomics

 3) Bioanalysis

 

 



  DMPK Key Technology
  항목 요소기술
 In vitro metabolism  Metabolic stability  Metabolic stability in microsomes, hepatocytes, plasma, blood
 Subcellular metabolism  Hepatocytes, S9 fraction, cytosol, microsomes, intestine
 Metabolic route and kinetics  Reaction phenotyping and kinetics of Phase I (CYPs) and Phase II (UGT) enzymes
 Interspecies comparative metabolism  Monkey, dog, hamster, mouse, rabbit, rat
 Metabolite Identification  Metabolite structure ID, toxic metabolite ID
 In vitro transport  Permeability test  Permeability in Caco-2, MDCK, LLC-PK1 cells
 Cryopreserved hepatocytes uptake
 Biliary excretion in sandwich cultured hepatocytes
 Transport system and kinetics  Uptake screening test in Xenopus oocytes
 Efflux screening test in MDCK-MDR1, MRPs, BCRP
 Pharmacogenetics study  Transport activity in wild type and variant transporters
 Drug-drug interaction  Inhibition  Screening of inhibitory potential of CYPs, UGTs, transporters
 Estimation of IC50 (Ki) value
 Mechanism-based inhibition  IC50 shift assay, reversibility assay
 Estimation of KI and kinact value
 Induction  Reporter assay
 mRNA expression level in hepatocytes
 Phenotyping assay using specific substrates
 In vivo PK (preclinical)  Mass balance  Mass balance study using radioactive or non-radioactive compounds
 Absorption  Estimation of bioavailability
 Distribution  Tissue distribution (brain, liver, kidney etc)
 Blood partitioning, Protein binding
 Metabolic profiling  Metabolites profiling and Met ID
 Excretion  Renal excretion, biliary excretion, enterohepatic circulation
 In vivo PK (human)  Translational Research  In vitro to in vivo extrapolation (SimCYP)
 Interspecies Pharmacokinetic Scaling
 Consultation of decision making for further clinical development
 Phase 0 study  Microdosing study
 Phase I study  First in human study
 Absolute bioavailability
 Drug-drug interaction potential study (cocktail study)
 Genotype based ADME study
 Special population (Gender, nephropathy, hepatic failure, Elderly)
 Bridging study


 

 


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이 페이지는 [장애인, 노인,등의 정보통신 접근성 향상을 위한 권장지침] 을 준수하여[한국형 웹 콘텐츠]접근성 지침1.0(2004년12월23일제정)의 검사 항목에 적합함