- 분자약물유전체학
  - 약물단백질체학
  - 화학유전체학
 
1) 분자약물유전체 (Pharmaco genetics)
주요연구분야

 1)약동학 관련 단백 유전자들의 유전적 다형성 연구

 2)약동학 관련 단백 변이유전자의 기능 연구

 3)약물반응 관련 단백의 발현조절 개인차 기전 연구
    - 약물반응 관련 단백의 발현조절 기전 연구
    - 유전자-환경 상호작용 연구

 4)고속 변이유전자 검색기술 개발

 

SNP Discovery and Scoring
   - Targets: Phase I/II, Transporters, Receptors
   - Methods
           Direct Sequencing
           Scoring for functional SNPs
           LD/Haplotype analysis
           Ethnic comparison
   - Projects
            CYP2C8
            UGT2B7/15, SULT1A1/2
            HNF1A, HIF1A, HNF6

HT Genotyping Techniques
   - Targets: Genes, Methods
   - Methods
           Functional SNP/haplotype determination (SNP, htSNP, ethnics)
           Selection of methods
           (Sequencing, PCR-RFLP, AS-PCR, Pyrosequencing, TaqMan, SNaPShot, Luminex, Chip,
           Illumina) 
           Simplex (SNP) vs. multiplex (haplotype, gene combination)
           Validation and patenting
   - Projects
            CYP1A2 SNaPShot
            CYP2D6 SNaPShot/Luminex-based Chip
            CYP2C9 TaqMan
            OCTs Pyrosequencing, etc.

In Vitro Functional Genetics
   - Targets: Genes, Proteins, Drugs
   - Methods
           Functional analysis of variant proteins
           Functional analysis of transporters' functions (transwell, substrates scr)
           Functional analysis of regulatory SNPs (promoter, splicing)
           Baculovirus, oocyte, cell culture, in vitro translation, etc.
   - Projects
          UGT1A4/7, CYP2D6, CYP2C8, etc.
            Haloperidol metabolites, lamivudine
            hOCTs, hOATs cell lines

Gene Regulations
   - Targets: Genes, Transcriptions
   - Methods
          mRNA expression profiling
          Protein expression profiling
          Cell culture/chemicals
          Protein degradations
      - Projects
            mRNA and protein expression profiling in human livers
            Functional variability of liver proteins (Phase I, Phase II)
            Promoter studies
            Drug interaction of induction (PXR-DDI, BCRP, salt) 

Spliceome : New challenge for individual variations besides genetic variations
   - Targets: Genes, Proteins
   - Method
           Splicing variant identification
           Putative ASV prediction
           Individual variations of ASV expressions
           Development of ASV expression quantification
   - Project
            ASV mRNA profiling in human livers
            Association studies of ASV and phenotypes (PXR-CYPs)
            CYP2C8, CYP2J2, etc

 
2) 약물단백질체(Phamarcoproteomics)
주요연구분야

1) Phosphoproteomics
2) Interactomics

Phosphoproteomics

Interactomics



3) 화학유전체학 (Chemical Genomics)



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이 페이지는 [장애인, 노인,등의 정보통신 접근성 향상을 위한 권장지침] 을 준수하여[한국형 웹 콘텐츠]접근성 지침1.0(2004년12월23일제정)의 검사 항목에 적합함