중점연구 유전자 목록 (Update Date : 2014.02.14)
Group Symbol Description Location
Phase I CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 15q24
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 19q13.2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 19q13.2
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 10q23.33
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 10q24
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 10q24.1-q24.3
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 22q13.1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 1p31.3-p31.2
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 19q13.1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 7q21.1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 7q21.1
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 7q21-q22.1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 19pter-p13.11
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 19p13.1
TBXAS1(CYP5A1) thromboxane A synthase 1 (platelet) 7q34-q35
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 8q11-q12
PGIS(CYP8A1) prostaglandin I2 (prostacyclin) synthase 20q13.13
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 15q21.1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 4q21-q23
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 12q24.2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1q42.1
Phase II UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 2q37
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 2q37
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 2q37
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 2q37
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 2q37
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 2q37
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2q37
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2q37
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2q37
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 4q13
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 4q13
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 16p12.1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 16p12.1
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 16p11.2
TPMT thiopurine S-methyltransferase 6p22.3
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 8p22
Transcription factor NR0B2(SHP) nuclear receptor subfamily 0, group B, member 2 1p36.1
NR1H3(LXRA) nuclear receptor subfamily 1, group H, member 3 11p11.2
NR1H4(FXR) nuclear receptor subfamily 1, group H, member 4 12q23.1
NR1I2(PXR) nuclear receptor subfamily 1, group I, member 2 3q12-q13.3
NR1I3(CAR) nuclear receptor subfamily 1, group I, member 3 (constitutive androstane receptor) 1q23.3
TCF1(HNF1A) HNF1 homeobox A 12q24.2
NR2A1(HNF4A) nuclear receptor subfamily 2, group A, member 1 20q12-q13.1
ONECUT1(HNF6) one cut homeobox 1 15q21.1-q21.2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 14q21-q24
Transporter ABCB1(MDR1) ?ATP-binding cassette, sub-family B (MDR/TAP), member 1 7q21.1
ABCC1(MRP1) ATP-binding cassette,sub family C (CFTR/MRP), member1 16p13.1
ABCC2(MRP2) ATP-binding cassette, sub-family C (CFTR/MRP), member 2 10q24
ABCC5(MRP5) ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3q27
ABCG2(BCRP) ATP-binding cassette, sub-family G (WHITE), member 2 4q22
SCN1A sodium channel, voltage-gated, type I, alpha subunit 2q24.3
SLC10A1(NTCP) solute carrier family 10 (sodium/bile acid cotransporter family), member 1 14q24.1
SLC10A2(ASBT) solute carrier family 10 (sodium/bile acid cotransporter family), member 2 13q33
SLC22A1(OCT1) solute carrier family 22 (organic cation transporter), member 1 6q26
SLC22A2(OCT2) solute carrier family 22 (organic cation transporter), member 2 6q26
SLC22A3(OCT3) solute carrier family 22 (extraneuronal monoamine transporter), member 3 6q26-q27
SLC22A6(OAT1) solute carrier family 22 (organic anion transporter), member 6 11q13.1-q13.2
SLC22A7(OAT2) solute carrier family 22 (organic anion transporter), member 7 6p21.2-p21.1
SLC22A9(OAT7) solute carrier family 22 (organic anion transporter), member 9 11q13.1
SLC22A12(URAT1) solute carrier family 22 (organic anion/urate transporter), member 12, SLC22A12 11q13.1
SLC28A1(CNT1) solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 15q25-26
SLC28A2(CNT2) solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 15q15
SLC28A3(CNT3) solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 9q22.2
SLC29A1(ENT1) solute carrier family 29 (nucleoside transporters), member 1 6p21.1-p21.2
SLC29A2(ENT2) solute carrier family 29 (nucleoside transporters), member 2 11q13
SLCO1B1(OATPC) solute carrier organic anion transporter family, member 1B1 12p
SLCO1B3(OATP1B3) solute carrier organic anion transporter family, member 1B3 12p12
SLCO2B1(OATP2B1) solute carrier organic anion transporter family, member 2B1 11q13
SLC47A1(MATE1) solute carrier family 47 (multidrug and toxin extrusion), member 1 17p11.2
Other ANXA6 annexin A6 5q32-q34
APOE apolipoprotein E 19q13.2
CALU calumenin 7q32.1
CDA cytidine deaminase 1p36.2-p35
CDC27 cell division cycle 27 homolog (S. cerevisiae) 17q12-q23.2
CHD5 chromodomain helicase DNA binding protein 5 1p36.31
DCK Deoxycytidine Kinase 4q13.3-q21.1
DKK3 dickkopf homolog 3 11p15.2
EFNB2 ephrin-B2 13q33
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9q22.1-q22.
GFRA1 GDNF family receptor alpha 1 10q26.11
GGCX gamma-glutamyl carboxylase 2p12
GNA14 guanine nucleotide binding protein (G protein), alpha 14 9q21
HLA-DRA major histocompatibility complex, class II, DR alpha 6p21.3
HLA-A HLA-A major histocompatibility complex, class I, A 6p21.3
HLA-B HLA-B major histocompatibility complex, class I, B 6p21.3
HLA-C HLA-C major histocompatibility complex, class I, C 6p21.3
HOMER2 homer homolog 2 15q24.3
HPCAL1 hippocalcin-like 1 2p25.1
IGF1R insulin-like growth factor 1 receptor 15q26.3
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 13q33
JARID2 jumonji, AT rich interactive domain 2 6p24-p23
KIAA0317 KIAA0317 14q24.3
KLKB1 kallikrein B, plasma (Fletcher factor) 1 4q34-q35
KRT12 keratin 12 17q12
LARS2 leucyl-tRNA synthetase 2, mitochondrial 3p21.3
LOC127406 ribosomal protein SA pseudogene 20 1p32.2
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 7p22
MTHFR 5,10-methylenetetrahydrofolate reductase (NADPH) 1p36.3
MYO3B myosin IIIB 2q31.1-q31.2
NCOA1 nuclear receptor coactivator 1 2p23
NQO1 NAD(P)H dehydrogenase, quinone 1 16q22.1
OPRM1 opioid receptor, mu 1 6q24-q25
P2Y12 purinergic receptor P2Y, G-protein coupled, 12 3q24-q25
PON1 PON1,paraoxonase 1 7q21.3
POR P450 (cytochrome) oxidoreductase 7q11.2
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2q13-q14
PROS1 protein S (alpha) 3q11.2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 6q27
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 5p15.2
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1q23-q25.1
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltran 1p31.1
TMEM99 transmembrane protein 99 17q21.2
TRPS1 trichorhinophalangeal syndrome I 8q24.12
TTN titin 2q31
TYMS thymidylate synthetase 18p11.32
TYMP thymidine phosphorylase 22q13.33
VKORC1 vitamin K epoxide reductase complex, subunit 1 16p11.2
WDR31 WD repeat domain 31 9q32
IL28B interleukin 28B (interferon, lambda 3),IL28B 19q13.13
ITPA ITPA, inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 20p
C20orf194 chromosome 20 open reading frame 194, C20orf194 20p13
ZIM2 zinc finger, imprinted 2 19q13.4


약물상호작용 고속 검색기술

약물/대사물 분석기술 보유 현황
Drug Analytical Method Drug Analytical Method
 Acetaminophen LC/MS/MS  Lamivudine HPLC/UV
 Alprazolam LC/MS/MS  Losartan HPLC/FD
 Amlodipine LC/MS/MS  Metformin LC/MS/MS
 Atorvastatin LC/MS/MS  Midazolam LC/MS/MS
 Benidipine LC/MS/MS  Moxifloxacin LC/MS/MS
 Bupropion LC/MS/MS  Nicotine LC/MS/MS
 Caffeine LC/MS/MS  Nortryptylin HPLC/UV
 Carbamazepine LC/MS/MS  Ofloxacin HPLC/FD
 Chlorpromazine LC/MS/MS  Omeprazole LC/MS/MS
 Chlorpropamide HPLC/UV  Rabeprazole LC/MS/MS
 Ciprofloxacin LC/MS/MS  Rebamipide HPLC/FD
 Clopidogrel LC/MS/MS  Rosiglitazone LC/MS/MS
 Dextromethorphan LC/MS/MS  Sibutramine LC/MS/MS
 Ebastine LC/MS/MS  Simvastatin LC/MS/MS
  Efavirenz LC/MS/MS  Tizanidine LC/MS/MS
 Fexofenadine HPLC/FD  Tolterodine LC/MS/MS
 Fluconazole HPLC/FD  Torasemide HPLC/UV
 Glimepiride LC/MS/MS  Verapamil HPLC/FD
 Haloperidol LC/MS/MS  Warfarin HPLC/FD
 Irbesartan LC/MS/MS  Udenafil LC/MS/MS
 Irinotecan LC/MS/MS  Zonisamide HPLC/UV
 Isotretinoin HPLC/UV  TB drugs (20종) LC/MS/MS

보유검체 시료현황
시료의 종류 갯수
whole blood 2763
blood cell 4
serum 5
plasma 161
DNA 베트남 161 655
african american 100
cocausian 100
이집트 102
중국 192
Tissue bladder 1 312
breast 2
colon 9
eye 6
kidney 3
liver 113
lung 2
muscle 3
placenta 3
rectum 4
spleen 1
stomach 6
urine 159



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