| 약물군 |
약 이름 |
관련 유전자 |
| 항응고제 |
Warfarin |
CYP2C9, VKORC1, CYP4F2 |
| 항혈소판제 |
Aspirin, Clopidogrel, Prasugrel |
CYP2C19, CES1/2, ABCB1, SLC22A, P2Y1/12, COX1 |
| 항고지혈증제 |
Atorvastatin, Fluvastatin, Iovastatin, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin |
CYP2C8/9, CYP2D6, CYP3A4/5, ABCA1, ABCB1/11, ABCC2, ABCG5/8, SLCO1B1, SLCO2B1, SLC10A1/2, HMG-CoA reductase, CYP7A1, POA1,
APOB, APOE |
마취유도제
및 마약성진통제 |
Fentanil, Alfentanil, Propofol, Morphin, Codein |
CYP2B6, CYP2D6, CYP3A4/5, UGT1A1/6/9, UGT2B7, ABCB1, ABCC2/3, OPRM1 |
| 항정신용제 |
Haloperidol, Risperidone, Aripiprazole, Olanzapine, Quetiapine, Ziprasidone, Chlorpromazine, Clozapine, Atomoxetine, Fluoxetine HCL |
CYP1A2, CYP2D6, CYP3A4/5, ABCB1, DRD2/3/4, 5-HT1A/2A/2C, 5-HTT, COMT, Clozapine toxicity-HLA B/DR/DQ, HSP 70, TNF |
| 수면진정제 |
Alprazolam, Diazepam, Etizolam, Lorazepam, Midazolam, Triazolam |
CYP2C19, CYP3A4/5, UGT2B15 |
| 항우울제 |
Amitriptyline, Bupropion, Citalopram, Fluoxetine, Imipramine, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Sertaraline, Trazodone, Venlafaxine |
CYP1A2, CYP2C19, CYP2D6, CYP3A4/5, SLC6A2/4, ABCB1, ABCC1, SERT |
| 항전간제 |
Carbamazepine, Clobazam, Clonazepam, Lamotrigine, Phenytoin, Valproic acid, Zonisamide |
CYP2C9/19, CYP3A4/5, UGT1A4, UGT2B7, SCN1, HLA-B, HLA-B*1502, GABA receptor
|
| 항종양제 |
Azathioprine, Capecitabine, Carboplatin, Cisplatin, Cyclophosphamide, Ifosfamide, Oxalipatin, Methotrexate, 5-FU, S-1, Cytarabine, Gemcitabine,
6-MP, 6-TG, Paclitaxel, Docetaxel, Etoposide, Irinotecan, Nilotinib, Doxorubicine, Imatinib, Gefitinib, Trastzumab, Busulfan, Dasatinib, Elrotinib, Cetuximab, Panitumumab |
TPMT, DPD, CYP1A1, CYP2A6, CYP2B6, CYP2C8/9/19, CYP2D6, CYP3A4/5, GST,, ALDH1A1, TP, TS, UGT1A1, ABCB1/3/11, ABCC1/2, ABCG2,
SLCO1A2, SLC19A1, SLC21A19, SLC31A1, SLC28A1/3, SLC29A1/2, c-Kit, HER2, Ph1, EGFR, KRAS |
| 항에스트로겐제 |
Tamoxifen, Anastrozole, Letrozole |
CYP1A2, CYP2C8/9, CYP2D6, CYP3A4/5, CYP19A1, ER |
| 항고혈압제 |
Metoprolol, Propranolol, Carvedilol, Captopril, Enalapril, Fosinopril, Imidapril, Lisinopril, Losartan, Valsartan |
CYP1A2, CYP2C9, CYP2D6, CES1, ABCB1, SLC15A1/3, SLC22A6/7/8, SLCO1B1, AGT, ACE, AGTR1/2, BDKRB2 |
| 천식 및 만성폐쇄성 폐질환 치료제 |
Albuterol, Formoterol, Salmeterol, Terbutaline, Isoproterenol, Aminophylline, Theophylline, Ipratropium, Montelukast, Zafirlukast, Budesonide, Fluticasone |
CYP1A2, CYP2C9, CYP3A4/5, MRP1, ADRB2, ALOX5, LTC4S, CysLTR1, GR, CRHR1/2/3, PDE4 |
| 당뇨병용제 |
Chlorpropamide, Glipizide, Gliburide, Glimepiride, Metformine, Nateglinide, Repaglinide |
CYP2C8/9, CYP3A4/5, SLC22A1/2, SLCO1B1, ABCC8, SLC2A2, KCNJ11 |
| 소염진통제 |
Aspirin, Celecoxib, Meloxicam, Flubiprofen, Tramadol |
CYP1A2, CYP2C9, CYP2D6, CYP3A4/5, CES1/2, ABCB1, SLC22A, COX1/2 |
| 면역억제제 |
Cylosporin, Mycophenolic acid, Tacrolimus, Leflunomide |
CYP2C9, CYP3A4/5, CYP3AP1, UGT1A8/9, UGT2B7, ABCB1, ABCC2, SLCO1B1 |
| 항궤양용제 |
Omeprazole, Esomprazole, Pantoprazole, Rabeprazole, Lansoprazole, Cimetidine, Raniditidine |
CYP2C19, CYP3A4/5, ABCB1/11, SLC22A, SLC47A1/2 |
| 항결핵제 |
Rifampin, Isoniazid, Pyrazinamide |
NAT2, CYP1A2 및 독성/치료실패 관련 후보유전자 (HLA B/DR/DQ, ADH, ALDH etc.) |
| 항바이러스제 |
Lamivudine, Abacavir |
IL28 ,ABCC4/5/11, ABCG2, SLC22A1/2/6, HLA-B*5701 |
| 발기부전치료제 |
Sildenafil, Tadalafil, Udenafil, Vardenafil |
CYP2C9, CYP3A4/5, ABCB1, ABCC4/5 |
