Publications
Product
| 지원과제 | cPMTb |
| 저자명 | Duong TH, Vu YT, Long NP, Phan NHN, Pham NKT, Sichaem J, Kieu NKD, Duong CB, Nguyen TT, Dang VS, Nguyen HT |
| 학회정보 | Pharmaceuticals(Basel). 5;16(9):1253 / 2023.09 |
| 제 목 | Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal Plants Dicranopteris linearis and Psychotria adenophylla |
| LINK | www.ncbi.nlm.nih.gov/pubmed/37765061/ |
| 게시일 | 2025-03-31 11:44:06 |
| 년도 | |
| 내용 | Little is known about the chemical and biological profiles of Dicranopteris linearis and Psychotria adenophylla. No previous studies have investigated alpha-glucosidase inhibition using extracts from D. linearis and P. adenophylla. In this paper, bioactive-guided isolation procedures were applied to the plants D. linearis and P. adenophylla based on alpha-glucosidase inhibition. From the most active fractions, 20 compounds (DL1-DL13 and PA1-PA7) were isolated. The chemical structures were elucidated using spectroscopic data and compared with those available in the literature. These compounds were evaluated for alpha-glucosidase inhibition, while a molecular docking study was performed to elucidate the mechanisms involved. Consequently, D. linearis and P. adenophylla might serve as a good potential for developing new antidiabetic preparations.
Keywords: Dicranopteris linearis; Psychotria adenophylla; alpha-glucosidase; flavonoids; molecular docking. |
