Publications
Product
| 지원과제 | BMRC, PRCDM |
| 저자명 | Lee SJ, Kim WY, Jarrar YB, Kim YW, Lee SS, Shin JG. |
| 학회정보 | Drug Metab Pharmacokinet. 28(4):372-7 / 2013.05 |
| 제 목 | Single nucleotide polymorphisms in SULT1A1 and SULT1A2 in a Korean population. |
| LINK | www.ncbi.nlm.nih.gov/pubmed/23358261 |
| 게시일 | 2014-02-12 14:47:59 |
| 년도 | 2013-International |
| 내용 | Abstract
SULT1A1 and SULT1A2 are encoded on the same chromatid, and exhibit a 96% amino acid similarity. To screen for genetic variants in these two closely related genes, SULT1A1 and SULT1A2 were directly sequenced in 50 healthy Koreans. A total of 30 variations were identified in SULT1A1: eight in exons, thirteen in introns, and nine in the 5'-untranslated region. With regard to SULT1A2, 21 variants were identified, comprising seven in exons, five in introns, and nine in the 5'-untranslated region. Among these 51 variations, one in SULT1A1 and eight in SULT1A2 were previously unidentified, which include three coding variants (SULT1A2 R37Q, 110G>A; SULT1A2 G50S, 148G>A; SULT1A2 F286L, 3819C>A) and one null allele (SULT1A2 E217Stop, 3542G>T). Two LD blocks, major haplotype structures, and 7 haplotype-tagging SNPs were determined together for SULT1A1 and SULT1A2 as a single set. Frequencies of common functional variants were compared among ethnic groups. Since these two SULT enzymes are on the same chromatid in a parallel direction with overlapping substrate specificities, a combined analysis using LD and haplotype-tagging single-nucleotide polymorphisms (SNPs) will facilitate understanding of the variations in the sulfation reactions of a wide range of substrates, as compared with analysis of individual genes. |
