| 지원과제 |
|
| 저자명 |
Kim KA, Park PW, Liu KH, Kim KB, Lee HJ, Shin JG, Park JY. |
| 학회정보 |
J Clin Pharmacol. 2008 Jan;48(1):66-72. |
| 제 목 |
Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone. |
| LINK |
www.ncbi.nlm.nih.gov/pubmed/18094221 |
| 게시일 |
2008-07-24 10:31:37 |
| 년도 |
2008-International |
| 내용 |
The authors studied the effect of rifampin, a dual inducer of CYP3A and P-glycoprotein, on the pharmacokinetics and pharmacodynamics of risperidone in humans. Ten healthy male subjects were treated daily for 7 days with 600 mg rifampin or with placebo. On day 6, a single dose of 1 mg risperidone was administered. Plasma risperidone and 9-hydroxyrisperidone concentrations were measured. Rifampin significantly decreased the mean area under the plasma concentration-time curve by 51% for risperidone, by 43% for 9-hydroxyrisperidone, and by 45% for the active moieties (risperidone + 9-hydroxyrisperidone). Rifampin also decreased the peak plasma concentration of risperidone by 38%, 9-hydroxyrisperidone by 46%, and the active moieties by 41%. The apparent oral clearance of risperidone approximately doubled after rifampin treatment. Thus, rifampin reduced the exposure to risperidone, probably because of a decrease in its bioavailability through the induction of CYP3A and probably P-glycoprotein. |
