| 지원과제 |
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| 저자명 |
Gwak J, Park S, Cho M, Song T, Cha SH, Kim DE, Jeon YJ, Shin JG, Oh S. |
| 학회정보 |
Int J Mol Med. 2006 Jun;17(6):1005-10. |
| 제 목 |
Polysiphonia japonica extract suppresses the Wnt/beta-catenin pathway in colon cancer cells by activation of NF-kappaB. |
| LINK |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d.. |
| 게시일 |
2006-09-22 10:43:15 |
| 년도 |
2006-International |
| 내용 |
Abnormal activation of the Wnt/beta-catenin pathway and subsequent up-regulation of beta-catenin response transcription (CRT) are associated with the development of colon cancer. Thus, the Wnt/beta-catenin pathway is an attractive target for chemoprevention and treatment of this cancer. We used a cell-based screen to identify a methanol extract of Polysiphonia japonica (EPJ) that suppresses the Wnt/beta-catenin pathway without altering the level of beta-catenin protein and reduces the expression of cyclin D1, which is a known beta-catenin/T cell factor (TCF)-dependent gene. EPJ inhibited the growth of various colon cancer cells. In addition, EPJ induced the nuclear translocation of nuclear factor-kappaB (NF-kappaB) in SW480 colon cancer cells. Our findings suggest that EPJ attenuates Wnt/beta-catenin signaling via activation of NF-kappaB and can potentially be used as a chemopreventive agent against colon cancer. |
