Publications
Product
| 지원과제 | |
| 저자명 | Park S, Gwak J, Cho M, Song T, Won J, Kim DE, Shin JG, Oh S. |
| 학회정보 | Mol. Pharmacol, 200605, 70(3) 960-966 |
| 제 목 | Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. |
| LINK | www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=.. |
| 게시일 | 2006-09-01 09:55:38 |
| 년도 | 2006-International |
| 내용 | Aberrant activation of Wnt/beta-catenin signaling and subsequent up-regulation of beta-catenin response transcription (CRT) is a critical event in the development of human colon cancer. Thus, Wnt/beta-catenin signaling is an attractive target for the development of anticancer therapeutics. In this study, we identified hexachlorophene as an inhibitor of Wnt/beta-catenin signaling from cell-based small-molecule screening. Hexachlorophene antagonized CRT that was stimulated by Wnt3a-conditioned medium by promoting the degradation of beta-catenin. This degradation pathway is Siah-1 and adenomatous polyposis colidependent, but glycogen synthase kinase-3beta and F-box beta-transducin repeat-containing protein-independent. In addition, hexachlorophene represses the expression of cyclin D1, which is a known beta-catenin target gene, and inhibits the growth of colon cancer cells. Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.
PMID: 16735606 |
