지원과제	cPMTb
저자명	Duong TH, Vu YT, Long NP, Phan NHN, Pham NKT, Sichaem J, Kieu NKD, Duong CB, Nguyen TT, Dang VS, Nguyen HT
학회정보	Pharmaceuticals(Basel). 5;16(9):1253 / 2023.09
제 목	Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal Plants Dicranopteris linearis and Psychotria adenophylla
LINK	www.ncbi.nlm.nih.gov/pubmed/37765061/
게시일	2025-03-31 11:44:06
년도
내용	Little is known about the chemical and biological profiles of Dicranopteris linearis and Psychotria adenophylla. No previous studies have investigated alpha-glucosidase inhibition using extracts from D. linearis and P. adenophylla. In this paper, bioactive-guided isolation procedures were applied to the plants D. linearis and P. adenophylla based on alpha-glucosidase inhibition. From the most active fractions, 20 compounds (DL1-DL13 and PA1-PA7) were isolated. The chemical structures were elucidated using spectroscopic data and compared with those available in the literature. These compounds were evaluated for alpha-glucosidase inhibition, while a molecular docking study was performed to elucidate the mechanisms involved. Consequently, D. linearis and P. adenophylla might serve as a good potential for developing new antidiabetic preparations. Keywords: Dicranopteris linearis; Psychotria adenophylla; alpha-glucosidase; flavonoids; molecular docking.